Brain Fog in Long COVID Linked to Increase in AMPA Receptors
Briefly

Brain Fog in Long COVID Linked to Increase in AMPA Receptors
"people in the world (about 400 million) suffering from long COVID. Long COVID is a chronic condition that can affect people who, at one time, had an acute COVID infection. Long COVID can persist for years, and unlike an acute COVID infection that mostly affects the lungs, it can also affect brain function. While the symptoms of long COVID can be very diverse, more than 80 percent of patients with"
"Brain fog is a colloquial term used to describe impairments in various brain functions, such as memory, decision-making, and reasoning. In heavily affected long COVID patients, brain fog can be so bad that they may be unable to work their normal jobs. Brain fog is difficult to treat, and one major problem is that scientists so far really have not understood very well which biological factors cause brain fog."
About 400 million people worldwide experience long COVID, and over 80% of those patients report brain fog. Brain fog impairs memory, decision-making, and reasoning and can prevent affected people from working. PET neuroimaging measured AMPA receptor density in 30 long COVID patients and 80 healthy volunteers and found a systemic increase in AMPA receptor density associated with cognitive impairment. AMPA receptors mediate fast excitatory synaptic transmission, so increased receptor density indicates synaptic alterations that may underlie cognitive symptoms and suggests potential molecular targets for diagnosis and treatment. Brain fog remains difficult to treat due to limited understanding of its biological mechanisms.
Read at Psychology Today
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