"The trial will look at how rapid MRI scans of the prostate could be combined with prostate-specific antigen (PSA) blood tests in order to improve the accuracy of cancer diagnosis. Currently, men over 50 can request a PSA test, which looks for abnormally high levels of protein in the blood, but this is unreliable, picking up many prostate cancers that would never need treatment, and missing others that do."
"The 42 million Transform trial is funded by Prostate Cancer UK and the National Institute for Health and Care Research. Hashim Ahmed, trial chief investigator, said: "Transform is truly game-changing the start of recruitment today marks a pivotal step towards getting the results men urgently need to make prostate cancer diagnosis safe and more effective so that we can unlock the potential of prostate cancer screening in the UK.""
A £42 million UK trial will evaluate combining rapid prostate MRI, PSA blood testing, and saliva DNA tests to improve prostate cancer screening. The trial will recruit men aged 50–74, with a lower age limit of 45 for Black men because of higher risk. Invitations are being sent by GPs and direct volunteering is not permitted. Current PSA testing can detect indolent cancers and miss aggressive ones, leading to overdiagnosis and harmful treatments. The trial aims to increase detection of clinically significant cancers while reducing unnecessary biopsies and treatments that cause incontinence and impotence. Prostate Cancer UK and the National Institute for Health and Care Research fund the study and encourage eligible men to participate when invited.
Read at www.bbc.com
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