Obesity has significantly increased, impacting over one billion people globally and linked to various metabolic disorders. Traditional treatments often present access issues and a struggle to maintain weight loss. Researchers at the Salk Institute are investigating microproteins, which play roles in health and disease. They utilized CRISPR gene editing to uncover genes that code for microproteins influencing fat cell growth and lipid storage. Findings suggest new microproteins as drug targets for treating obesity and related disorders, emphasizing CRISPR's role in discovering these potential therapeutic avenues.
CRISPR screening is extremely effective at finding important factors in obesity and metabolism that could become therapeutic targets, showcasing the potential of microproteins.
The study identifies new microproteins that could serve as drug targets for obesity and metabolic disorders, ultimately helping to combat the global obesity epidemic.
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