"The research, published in Nature Medicine on 9 March, reveals that taking a daily supplement for two years slowed biological ageing in older adults by around four months, compared with those who didn't take them. The effect was more pronounced in people who already showed signs of accelerated biological ageing, meaning that their calculated biological age was greater than their chronological age."
"To calculate people's biological ages at the time of each sample, the team analysed five epigenetic 'clocks' in the blood samples. These clocks are biomarkers that measure DNA methylation - patterns of molecular tags on DNA - at specific sites in the genome. Methylation levels increase or decrease at particular sites in a relatively predictable manner with age."
"The aim of studies like this is "not just identifying how to live longer, but also how to live better", says study co-author Howard Sesso, an epidemiologist at Brigham and Women's Hospital in Boston, Massachusetts. Although it's too early to link the data to clinical outcomes, "the multivitamin intervention appeared to be on that type of trajectory over two years.""
A study published in Nature Medicine examined 958 healthy participants averaging 70 years old from the COSMOS randomized controlled trial. Researchers analyzed blood samples at enrollment and after 12 and 24 months using five epigenetic clocks that measure DNA methylation patterns—molecular tags on DNA that change predictably with age. Results showed that daily multivitamin supplementation significantly slowed biological aging markers compared to placebo. The effect was more pronounced in individuals with accelerated biological aging, where calculated biological age exceeded chronological age. While clinical outcomes remain unclear, researchers suggest the intervention shows promising trajectory for improving not just longevity but quality of life in older adults.
Read at Nature
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