Detroit hosts Cleveland at Comerica Park on Thursday at 1:10 p.m. ET. Casey Mize is the Tigers’ probable starter, entering with a 2-2 record, a 2.43 ERA, and 39 strikeouts in 37 2/3 innings. In his most recent start against Toronto, he threw six scoreless innings and allowed two hits. Mize has a .211 opponent batting average and four quality starts, and he is averaging 5.3 innings per appearance. Joey Cantillo is the Guardians’ probable starter with a 3-1 record and a 3.40 ERA. He last pitched five innings versus Cincinnati, allowing four earned runs on four hits, and he has a 1.351 WHIP. Cantillo has quality starts in two of his 10 starts and has pitched at least five innings in three straight games.
"Mize gets the start for the Tigers, his eighth of the season. He is 2-2 with a 2.43 ERA and 39 strikeouts in 37 2/3 innings pitched. In his last appearance on Saturday against the Toronto Blue Jays, the right-hander threw six scoreless innings while surrendering two hits. In seven games this season, the 29-year-old has put up a 2.43 ERA and 9.5 strikeouts per nine innings, while giving up a batting average of .211 to his opponents. Mize has four quality starts under his belt this year. Mize will try to secure his sixth outing of five or more innings pitched this season. He's averaging 5.3 innings per appearance. In two of his appearances this season he did not give up an earned run."
"Cantillo (3-1) will take to the mound for the Guardians and make his 11th start of the season. The left-hander's last appearance was on Saturday, when he threw five innings against the Cincinnati Reds, giving up four earned runs while allowing four hits. The 26-year-old has an ERA of 3.40, a 1.88 strikeout-to-walk ratio and a WHIP of 1.351 in 10 games this season. In 10 starts this season, he's earned two quality starts. Cantillo has pitched five or more innings in three straight games and will look to extend that streak. He has finished one appearance without allowing an earned run in 10 chances this season."
"When: Thursday, May 21, 2026 at 1:10 p.m. ET Where: Comerica Park in Detroit, Michigan How to watch on TV: DSN and CleGuardians.TV Probable Pitchers: Casey Mize - DET (2-2, 2.43 ERA) vs Joey Cantillo - CLE (3-1, 3.40 ERA)"
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