The Philadelphia Phillies host the Cleveland Guardians in the series opener on Friday, May 22, 2026, with first pitch scheduled for 6:40 p.m. ET at Citizens Bank Park. The game is available on NBCS-PH and CleGuardians.TV, with a live stream available via Fubo. The Phillies enter with 20 wins in 36 moneyline-favorite games, 62 home runs ranking sixth in baseball, and a .393 slugging percentage ranking 11th. Their team ERA is 4.31, ranking 21st, and their WHIP is 1.355, ranking 20th. The Guardians have won 13 of 23 games as underdogs, hit 53 home runs, and post a 3.67 ERA ranking eighth, with a 1.260 WHIP ranking 12th.
"The Philadelphia Phillies (25-25), led by Bryce Harper, host Jose Ramirez and the Cleveland Guardians (30-22) at 6:40 p.m. ET on Friday in a series opener. Find out how to watch the Philadelphia-Cleveland matchup below. When is Phillies vs. Guardians and when does it start? This contest between the Phillies and Guardians will take place on Friday, May 22, 2026. You can expect the opening pitch at 6:40 p.m. ET."
"The Phillies and Guardians will take to the field at Citizens Bank Park for this matchup on May 22, and if you'd like to see the action live, get your tickets now from Vivid Seats! What channel is the game on? You can catch this game live on NBCS-PH and CleGuardians.TV. Watch the Phillies vs. Guardians live stream on Fubo Live Stream Online: Sign up for Fubo today!"
"The Phillies have won 20 of the 36 games they were listed as the moneyline favorite this season (55.6%). Philadelphia ranks sixth in baseball with 62 home runs. They average 1.2 per game. The Phillies rank 11th in baseball, slugging .393. Philadelphia's 4.31 team ERA ranks 21st across all MLB pitching staffs. The Phillies average MLB's 20th-ranked WHIP (1.355)."
"The Guardians have been underdogs in 23 games this season and won 13 (56.5%) of those contests. Cleveland ranks 16th in Major League Baseball with 53 home runs. The Guardians rank 20th in the majors with a .377 team slugging percentage. Cleveland has pitched to a 3.67 ERA this season, which ranks eighth in baseball. The Guardians rank 12th in MLB with a combined 1.260 WHIP this season."
Read at Bleacher Nation
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