The Chicago White Sox will open the 2026 season at the Milwaukee Brewers on March 26, marking the first Opening Day against a National League opponent for the club. The home opener at Guaranteed Rate Field is April 2 against the Toronto Blue Jays. Crosstown series with the Cubs are scheduled May 15-17 at the South Side and Aug. 17-19 at Wrigley Field. Other National League visitors include Washington, Atlanta, the Dodgers, Cincinnati, the Mets, Pittsburgh and Colorado on specified dates. Road interleague trips include Miami, Arizona, San Diego, San Francisco, Philadelphia and St. Louis. The Sox last started a season at Milwaukee in 1995, and the rebuilding team is trying to avoid a third straight 100-loss season.
The White Sox will open the 2026 season on the road against the Milwaukee Brewers on March 26, marking the first time they've faced a National League opponent on Opening Day. The Sox and Major League Baseball on Tuesday released next year's schedule, which has the Toronto Blue Jays coming to Rate Field for the Sox' home opener April 2. Crosstown series against the Cubs will take place May 15-17 on the South Side and Aug. 17-19 at Wrigley Field.
Other National League visitors to Rate Field will include Washington (April 24-26), Atlanta (June 9-11), the Dodgers (June 12-14), Cincinnati (August 11-13), the Mets (June 21-23), Pittsburgh (Sept. 8-10) and Colorado (Sept. 25-27). And aside from Milwaukee, the Sox will hit the road for interleague matchups in Miami (March 30-April 1), Arizona (April 21-23), San Diego (May 1-3), San Francisco (May 22-24), Philadelphia (June 5-7) and St. Louis (Sept. 11-13).
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