"The conversation around cannabis often gets reduced to one metric: THC percentage. For many consumers, higher THC equates to stronger effects. Yet research shows that cannabis cannot be understood by THC alone. The plant is a symphony of compounds-cannabinoids, terpenes, flavonoids, and more-that interact in complex ways. When these components are consumed together, they create what scientists and patients call the entourage effect, a phenomenon where the whole plant produces greater effects than any single compound in isolation."
"The term "entourage effect" was first introduced in 1998 by Israeli researchers Raphael Mechoulam and Shimon Ben-Shabat. Their studies revealed that cannabinoids work synergistically when consumed together, enhancing or modulating each other's effects. For example, while THC is known for its psychoactive properties, pairing it with CBD can temper anxiety, extend the duration of relief, or reduce negative side effects. Likewise, terpenes such as myrcene, limonene, or pinene may shape the type of high experienced, adding sedating, uplifting, or clarifying qualities."
"The entourage effect essentially shows that cannabis is more than the sum of its parts. Just as a single violin can't replicate the impact of a full orchestra, isolated compounds cannot deliver the same depth of experience as a whole-plant product. Cannabinoids: The Core of the Symphony At the heart of cannabis are cannabinoids, the plant-derived compounds that interact with the body's endocannabinoid system. More than 100 cannabinoids have been identified, but a few play outsized roles in shaping effects."
THC percentage alone does not determine cannabis effects because the plant contains cannabinoids, terpenes, flavonoids, and other compounds that interact synergistically. This synergistic interaction, known as the entourage effect, produces combined effects stronger or different than isolated compounds. Pairing THC with CBD can reduce anxiety, extend relief, or lessen negative side effects. Terpenes such as myrcene, limonene, and pinene influence sedation, uplift, or clarity of the high. More than 100 cannabinoids exist, with a few driving most effects. Whole-plant products often feel more balanced and nuanced, shifting quality, formulation, and wellness considerations.
Read at stupidDOPE | Est. 2008
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