"EZH2 is a well-known oncogene in prostate cancer, but our work focuses on uncovering its non‑canonical functions - especially how it interacts with RNA modifications."
"We observed a direct interaction between EZH2 and ADAR, the enzyme that conducts A‑to‑I RNA editing, and this interaction reshapes the global RNA editing pattern in cancer cells."
"Our findings may help explain why targeting EZH2 alone has shown limited success in solid tumors: because EZH2 can indirectly stabilize oncogenic transcripts and increase their expression."
EZH2, a protein known for modifying DNA-packaging histones, has been found to directly influence RNA editing in prostate cancer. This discovery connects two significant epigenetic processes and clarifies the disruption of RNA editing patterns in tumors. The study reveals that EZH2 interacts with ADAR, the enzyme responsible for A-to-I RNA editing, reshaping RNA editing patterns in cancer cells. This interaction may explain the limited success of targeting EZH2 alone in treating solid tumors, as it can stabilize oncogenic transcripts and enhance their expression.
Read at News Center
Unable to calculate read time
Collection
[
|
...
]