Wine typically comes in 750-milliliter bottles and domestic beer often comes in 12-ounce (≈355 milliliter) cans, yielding about 2.11 cans per bottle by volume. Alcohol by volume (ABV) determines alcohol content: a 750 ml bottle at 14% ABV contains 105 ml of pure alcohol, whereas 750 ml of 5% beer contains 37.5 ml. That calculation implies roughly 5.9 twelve-ounce (5% ABV) beers equal one 750 ml bottle of 14% wine, so a six-pack of typical domestic beer provides just over a bottle's worth of alcohol. Some craft beers can have higher ABV, for example around 6.5%.
Wine most commonly comes in a 750-milliliter bottle, whereas beer comes in different sizes. Let's say you've been drinking 12-ounce cans of domestic beer. To make science teachers everywhere proud, we're going to translate ounces into milliliters so we stay consistent. 12 ounces is roughly 355 milliliters, which means that when purely looking at volume, there are 2.11 12-ounce cans in a single bottle of wine.
What matters more is the alcohol by volume (ABV). Let's say the wine is a common 14% ABV, and your beer is a typical 5% ABV. For a 750-milliliter bottle of wine, that means you are drinking 105 milliliters of alcohol. In 750 milliliters of beer, you are getting 37.5 milliliters of alcohol. Crunching the numbers, that means you would need to drink 5.9 cans of beer to equal the amount of alcohol in a bottle of wine.
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