Research from Northwestern University reveals that piperacillin is effective against Lyme disease in mice at a dosage 100 times lower than doxycycline, the standard treatment. The study indicates that this lower dose minimizes disruption to gut microbiota, which is a significant drawback of doxycycline and other broad-spectrum antibiotics. Additionally, doxycycline is ineffective for 10-20% of patients and not approved for children, highlighting the need for better treatment options as Lyme disease becomes more prevalent due to climate changes.
Powerful, broad-spectrum antibiotics that kill extracellular bacteria are seen as the most effective medication because physicians want to just kill the bacterium and don't care how.
Piperacillin effectively cured mice of Lyme disease at a dose 100 times smaller than doxycycline, the current gold-standard treatment.
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