Researchers at Northwestern Medicine have developed innovative eyedrops that employ synthetic nanoparticles to encourage the regeneration of limbal epithelial stem cells, crucial for corneal health. This treatment addresses damage from mustard keratopathy and inflammatory eye disorders, countering limitations of traditional corticosteroids, which often fail to promote healing and can cause side effects. The synthetic lipoproteins are inspired by natural HDL particles, aiming to harness their anti-inflammatory properties to restore eye function effectively and potentially prevent blindness caused by limbal stem cell deficiency.
"By taking a page out of nature's playbook, we could begin to synthesize these types of materials and control their sizes, shapes and compositions."
"Topical corticosteroids have commonly been used to treat inflammation preceding LCSD, but adverse side effects from long-term steroid use can occur."
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