Carl H. June, aged 72, the pioneer of CAR-T therapies, predicts a shift in medicine towards personalized gene therapies that could potentially cure various diseases. Although these advances in medical treatments are emerging, they will take years, if not decades, to implement widely. His work particularly focuses on cancer treatments by genetically modifying T cells to combat tumors effectively. He has recently gained recognition for fine-tuning approaches to treat solid tumors, particularly glioblastoma, through advanced methods such as dual targeting and direct infusion into the site of the tumors.
The transformation in medicine driven by personalized gene therapies promises cures for many diseases, including cancer, diabetes, and autoimmune conditions, but widespread application may take decades.
By infusing modified T cells into the blood, CAR-T therapies have been effective for blood cancers, but extending their success to solid tumors presents significant challenges.
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