#therapeutic-development

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Public health
fromNature
1 day ago

Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor - Nature

Marburg virus causes 73% case fatality rate in humans with no licensed therapeutics or vaccines available, unlike Ebola virus which has approved treatments and vaccines despite lower mortality.
#alzheimers-disease
fromHarvard Gazette
5 days ago
Health

'A moment of real possibility' in Alzheimer's care - Harvard Gazette

Disruptions to fat metabolism in the brain, particularly linked to the APOE4 gene, may be a key mechanism in Alzheimer's disease beyond amyloid plaque accumulation.
fromNature
1 month ago
Medicine

Cancer might protect against Alzheimer's - this protein helps explain why

A protein secreted by cancer cells infiltrates the brain and breaks apart misfolded protein clumps linked to Alzheimer's, suggesting a potential therapeutic pathway.
Health
fromNews Center
7 months ago

Novel Molecular Mechanisms Inform Targeted Therapies for Chronic Kidney Disease - News Center

Genetic mutations in the PKD2 gene cause polycystic kidney disease through defects in ion channel function.
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