Betley and his colleagues were curious about what happens in the brain as people get stronger through exercise. They decided to focus on the ventromedial hypothalamus, a brain region that regulates appetite and blood sugar. The team then zeroed in on a group of neurons in that region that produce a protein called steroidogenic factor 1 (SF1), which is known to play a part in regulating metabolism. A previous study found that the deletion of the gene that codes for SF1 impairs endurance in mice.
A ticking clock, heavy breathing, the squeak of sneakers on the dance floor, and the voices of runners who came to the sport from unconventional backgrounds. These are the sounds that score choreographer Alyssa Mitchel's cast of dancers as they reinterpret what it means to push your body to its limits in Mitchel's new multimedia dance production, "Endure," at Dance Mission Theater, which has its first performance on Oct. 3.