Our previous groundbreaking work demonstrated that translocations associated with human leukemia are associated with a gene that regulates the rate of transcription elongation in mammalian cells. Further study has solidified that transcription elongation control is a key regulatory step and this perturbation causes cancer and other diseases including aging.
By targeting the BRD4-containing CDK9 complex in cultured cells, the scientists discovered that cell responses to oxygen deprivation were also reduced.
#multiprotein-complex #oxygen-deprivation #cancer-research #transcriptional-regulation #brd4-containing-cdk9-complex
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