"Their groundbreaking discovery revealed a completely new principle of gene regulation that turned out to be essential for multicellular organisms, including humans," the assembly said in a statement explaining the importance of their work.
The Nobel Assembly at the Karolinska Institute, which awarded the prize, said the duo's discovery is "proving to be fundamentally important for how organisms develop and function."
Ambros and Ruvkun were initially interested in genes that control the timing of different genetic developments, ensuring that cell types develop at the right time.
Perlmann said he spoke to Ruvkun by phone shortly before the announcement, and he quite rapidly was quite excited and happy, when he understood what it was all about.
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