The goal of this concept is to encourage research to define the mechanisms and roles of T-cells in HIV/central nervous system (CNS) reservoir seeding, persistence and neuropathogenesis. This research will be critical for developing therapeutic strategies for targeting CNS reservoirs and ongoing neuroinflammation that drive CNS comorbidities.
HIV targets the CNS early in infection, and HIV-infected individuals can experience mild forms of neurological impairments even under ART. CD4+ T-cells and monocytes mediate HIV entry into the brain and constitute a source for HIV persistence and neuronal damage.
Major gaps remain in understanding the mechanisms and roles of T-cells in CNS reservoir seeding, viral persistence, and neuropathogenesis.
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