Many experts agree that depression is not a singular illness but a large family with various causes, making personalized treatments challenging.
Contrasting reactive depression (triggered by stressful life events) with endogenous depression (caused by biological factors) is a common sub-typing approach, though deemed oversimplified.
Genes and stressors interact to increase the risk of depression, challenging the binary classification of depression as reactive or endogenous.
The Australian Genetics of Depression Study aimed to investigate the role of genes and stressors in depression to assess the validity of classifying depression into reactive or endogenous categories.
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