Fasting elicits a range of health benefits, yet the mechanisms at play remain underexplored. Our study reveals how specific changes in translation during fasting facilitate metabolic adaptations.
We found that during fasting, eIF4E phosphorylation is heightened, controlling the translation of genes critical for lipid catabolism and ketone body production.
Inhibition of P-eIF4E disrupts the fasting response through impaired ketogenesis, revealing its crucial role in processing fatty acids for energy generation.
This new lipid-mediated signaling pathway highlights the connection between selective translation control and ketogenesis, paving the way for dietary interventions in cancer treatment.
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