A hallmark of neurodegenerative diseases involves protein aggregation like alpha-synuclein in Parkinson's, leading to cellular dysfunction and neuronal damage.
Deficits in protein trafficking between cell organelles contribute to protein buildup, disrupting waste disposal pathways and promoting aggregation in Parkinson's.
Study identified RNA-binding proteins NONO and SFPQ in the nucleus, distinct from typical cytoplasmic alpha-synuclein pathology in Parkinson's affected neurons.
#parkinsons-disease #neuronal-protein-aggregation #cellular-mechanisms #therapeutic-targets #neurodegenerative-diseases
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