The discovery and use of powerful antimicrobial agents have saved many lives, but they have also led to the rise of multidrug-resistant organisms, presenting a significant global health threat.
Gram-negative Enterobacteriaceae such as Escherichia and Klebsiella are now prominent multidrug-resistant pathogens that offer limited treatment options, challenging existing therapeutic protocols.
Inflammatory bowel disease is associated with dysbiosis and enrichment of Enterobacteriaceae, exacerbating intestinal inflammation and increasing susceptibility to systemic infections.
Fecal microbiota transplantation has shown promise in reducing Enterobacteriaceae levels, but challenges like mixed results and safety concerns must be addressed for effective clinical application.
#antimicrobial-resistance #gram-negative-bacteria #inflammatory-bowel-disease #fecal-microbiota-transplantation #healthcare-challenges
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