A win at Old Trafford could secure a top-six spot for the Magpies, leaving eight-placed Man United behind while Chelsea, who sit seventh, face Brighton on Wednesday night.
It has been a tough season for Erik ten Hag's Red Devils with just one win in eight Premier League games after being beaten at home to Arsenal on Sunday.
Newcastle have won three games in a row against the Red Devils, showing a strong recent record against Manchester United.
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