WRN depletion induces DNA damage, anti-proliferative effects, mitotic defects, and apoptosis specifically in MSI cancer models, not in MMR-intact cells, suggesting a potential therapeutic strategy for MSI cancers.
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WRN depletion induces DNA damage, anti-proliferative effects, mitotic defects, and apoptosis specifically in MSI cancer models, not in MMR-intact cells, suggesting a potential therapeutic strategy for MSI cancers.