My colleagues and I have recently shown, in mice, that a single, relatively simple vaccine can protect against a range of coronaviruses - even ones that are yet to be identified. This is a step towards our goal of what is known as 'proactive vaccinology,' where vaccines are developed against pandemic threats before they can infect humans.
These mosaic nanoparticles use a type of protein superglue technology that irreversibly links two different proteins together. The vaccine is focused on a sub-group of coronaviruses called arboviruses that includes the viruses that cause Covid-19, SARS, and several bat viruses that have the potential to infect humans.
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