Recent research by Akiko Kojima-Yuasa's team at Osaka Metropolitan University explores the effects of ethyl p-methoxycinnamate from kencur ginger on cancer cells. The compound inhibits ATP production by disrupting lipid metabolism and de novo fatty acid synthesis, challenging previous theories focusing solely on glycolysis. The study identifies a significant adaptability within cancer cells as increased glycolysis may serve as a survival mechanism despite the compound's inhibition of lipid synthesis. This research provides critical insights into cancer metabolism, expanding the established Warburg effect framework.
The study reveals that ethyl p-methoxycinnamate disables cancer cells' lipid metabolism, highlighting an alternative energy pathway that could be targeted for cancer treatments.
The findings expand upon the Warburg effect theory by showing that cancer cells' adaptability through increased glycolysis serves as a survival mechanism.
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