It is too early to tell whether the recent slowdown in the disinflationary process will be long lasting, Fed vice chairman Philip Jefferson told the Mortgage Bankers Association conference in New York.
In Europe, the German Dax index was down 0.2% at the close and the Cac 40 in France ended 0.7% down.
Sterling was stable ahead of key inflation data from the Office for National Statistics on Wednesday morning.
AstraZeneca shares rose after it announced it planned to double profits to 80 billion dollars (62.8 billion) by 2030.
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