The series finale will mark the Boston debut of Zack Short, who the club acquired via trade with the New York Mets on Wednesday.
Speaking of new arrivals, Dominic Smith played his first game with the Red Sox in Wednesday night's win.
With a southpaw on the hill for San Francisco on Thursday, it will be Bobby Dalbec at first base for Alex Cora's crew.
The home nine will give the ball to Josh Winckowski, who pitched three shutout innings against the Chicago Cubs on Saturday.
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