Jaylen Brown scored 32 points, Derrick White made seven 3-pointers and added 25, leading the Celtics to a 120-95 victory over the Cavaliers.
The Celtics hit 18 of 46 3-pointers, building a 15-point lead into the fourth quarter and extending it to 102-79 with a 10-2 run at the start.
Donovan Mitchell scored 33 points for the Cavaliers, becoming the fourth player in history to score 30+ points in six straight playoff series openers.
Both teams played without their starting centers, with Jarrett Allen missing for the Cavaliers and Kristaps Porzingis sidelined for the Celtics.
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