Melatonin, a hormone naturally produced in the body, is being explored as a potential preventive treatment for migraine due to its antioxidant effects, regulation of neurotransmitter activity, and inhibition of pain-related peptides.
Researchers conducted a double-blind, randomized clinical trial with 60 episodic migraine patients, showing that melatonin supplementation, in addition to standard preventive medication, led to a significant reduction in the frequency and severity of migraine attacks over two months.
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