#small-cell-lung-cancer
#small-cell-lung-cancer

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Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer - Nature

Tumour cell plasticity and cell-of-origin shape neuroendocrine tumour subtypes; tuft-like POU2F3-driven cancers likely originate from tuft cells rather than pulmonary neuroendocrine cells.

Medicine

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4 weeks ago

Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors - Nature

Disrupting the cyclin A–E2F1 interaction selectively induces apoptosis in RB1/TP53-deficient small cell lung cancer, offering a synthetic lethal therapeutic strategy.

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#small-cell-lung-cancer#small-cell-lung-cancer

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer - Nature

Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors - Nature

#small-cell-lung-cancer
#small-cell-lung-cancer