#mri-tractography

#mri-tractography

Young, two-month-old lab mice housed with older, 18-month-old mice showed really impaired cognition. Researchers exposed young mice raised in a sterile, microbe-free environment to gut bacteria from old mice, causing the younger animals to perform worse on cognitive tests, as if they had prematurely aged, just like the cohoused mice.

They created an artificial 'mental map', with pleasantness along one axis and bodily reactions along the other, and charted how the brain responded while watching clips from films. The results revealed clear groupings in the way that our brains represent emotion - with guilt, anger and disgust in one corner and happiness, satisfaction and pride in the other.

We found that a simple, guideline-based exercise program can make the brain look measurably younger over just 12 months. Many people worry about how to protect their brain health as they age. Studies like this offer hopeful guidance grounded in everyday habits. These absolute changes were modest, but even a one-year shift in brain age could matter over the course of decades.

The human brain is engineered to ignore most of what it sees and hears, according to the neuroscientists I interviewed for the audio original Viral Voices. If that's the case, how are you supposed to make a memorable impression? The empowering news is that if you understand how the brain works, what it discards, and what it pays attention to, you'll be far more persuasive than you've ever imagined. Persuasive people have influence in their personal and professional lives.

According to University of Michigan neuroscientists, not only can their AI vision language model diagnose neurological disorders from MRI scans with high performance accuracy, but it also has foundation model capabilities, making it a flexible, general-purpose solution that can be tailored for a wide variety of medical imaging. "These results demonstrate that Prima has foundation model properties, and reported performance will continue to improve with additional health system training data and larger compute budgets," wrote the study's authors in the preprint.

Anyone living with schizophrenia understands the true limitations of current treatment options. Antipsychotics remain the single leading treatment for the disorder, and they are riddled with undesirable side effects. Weight gain, tardive dyskinesia, and excessive drowsiness are a few. Much research is devoted to expanding the range of medication options, and few academics have pursued other avenues. However, there is a possibility that treatment for schizophrenia can be approached through cellular methods if long-term research validates early signs of hope.

A groundbreaking study found that adults who sit for 10 or more hours daily face a significantly higher risk of dementia compared to those who sit less. The research, which tracked over 50,000 adults using wearable devices, revealed that the risk increases dramatically after crossing that 10-hour threshold.

There are lots of reasons why relationships fall apart; all kinds of incompatibilities can doom romance. Some are trivial, but occasionally there might be something more profound at the root of an estrangement. Recently, the concept of the "frontal lobe breakup" appeared in popular culture. The idea is that the final stage of development in the executive regions of the brain-the frontal lobes-changes someone's perspective about their relationship. The onset of advanced cognitive skills in one partner creates a gap in maturity too big to bridge.

Artificial intelligence (AI) machine learning is making a difference in assistive technology to help restore movement for the paralyzed. A new study in the American Institute of Physics journal APL Bioengineering shows how AI has the potential to restore lower-limb functions in those with severe spinal cord injuries (SCIs) by identifying patterns in brain signals captured noninvasively via electroencephalography (EEG).

Summer passed Valerie Zeko by when she was 27, as she vegged out on the couch watching TV instead of seeing friends or exploring the overcast beach near her house. She later learned that period was her first episode of depression. I felt like the fog was in my head as well as outside, said Zeko, now 57, describing the mood disorder that would squelch her happiness, motivation and self-esteem for 28 years until she finally found effective treatment.

I am a worrier, and have been for most of my life. At some point, someone dear and smart teased me that I worry about the wrong things. The things that hit me, she noted, were never the things I worried about. For a while that left me feeling like an incompetent worrier-until my research caught up. I realized that the things I worry about often don't end up hurting me precisely because worrying helps me diffuse them ahead of time.

Most people will forget a name, misplace their phone, or lose track of a conversation at some point. Usually, those moments pass without much thought. But for many adults, especially as they age, small lapses can trigger a much deeper fear: Is this the beginning of cognitive decline? As a neurologist, I hear this concern often. And as a researcher, I have learned something important: Worry about cognition and cognitive disease are not the same thing.

Brain implants are beginning to help people with severe disabilities to speak and even sing in near-real time. Now, a company wants to read people's minds and treat mental conditions without implanting electrodes deep into the brain by using ultrasound - high-frequency sound waves above the range of human hearing. Merge Labs, which launched last month with only a vague description of its goals, is one of many companies in a booming brain-computer interface (BCI) market.

They then used emerging mathematical methods to isolate signals originating from nine brain regions previously implicated in mediating consciousness and examined connections between pairs of these regions. Among them were the parietal cortex, which is at the top of the brain about halfway between the forehead and the back of the skull; the occipital cortex, at the back of the head; and several small, deeper structures, such as one called the thalamus.

If you get migraines, you already know they don't just stay in your head. The pounding pain might be the headline symptom, but the real story is how an attack can throw your entire body out of whack - making light feel blinding, everyday sounds unbearable, and even simple texts impossible to answer. That's because a migraine isn't just about sore neck muscles or scalp tension. It's a full-body neurological event, driven by a cascade of changes in the brain.

The team, which is being led by Jülich neurophysics professor Markus Diesmann, will leverage the Joint Undertaking Pioneer for Innovative and Transformative Exascale Research (JUPITER) supercomputer for their simulation. JUPITER is currently the fourth most powerful supercomputer in the world according to the TOP500 list, and features thousands of graphical processing units. The team demonstrated last month that a " spiking neural network " could be scaled up and run on JUPITER, effectively matching the cerebral cortex's 20 billion neurons and 100 trillion connections.

There was a group of neurons that predicted the wrong answer, yet they kept getting stronger as the model learned. So we went back to the original macaque data, and the same signal was there, hiding in plain sight. It wasn't a quirk of the model - the monkeys' brains were doing it too. Even as their performance improved, both the real and simulated brains maintained a reserve of neurons that continued to predict the incorrect answer.

Tumours lure and then hijack nearby sensory neurons to boost their own growth. The cancer cells use these neurons to send a signal to the brain that subdues the activity of immune cells around the tumour, which allows it to grow unchecked. When researchers deactivated these neurons in mice with lung cancer, they saw "a huge, dramatic reduction" in tumour growth - more than 50% - says cancer immunologist and study co-author Chengcheng Jin.

It might come as a surprise to learn that the brain responds to training in much the same way as our muscles, even though most of us never think about it that way. Clear thinking, focus, creativity, and good judgment are built through challenge, when the brain is asked to stretch beyond routine rather than run on autopilot. That slight mental discomfort is often the sign that the brain is actually being trained, a lot like that good workout burn in your muscles.