#microglia-replacement

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Medicine
fromNature
1 week ago

Daily briefing: Universities made the modern world - now they must survive it

One-time gene therapy markedly slowed Huntington's progression; microglial replacement and AI for preserving Holocaust testimony offer promising biomedical and archival advances.
fromNature
1 week ago

Swapping old immune cells in the brain with fresh ones could treat disease

A fresh supply of the immune cells that keep the brain tidy might one day help to treat a host of conditions, from ultra-rare genetic disorders to more familiar scourges, such as Alzheimer's disease. In the past few months, a spate of new studies have highlighted the potential of a technique called microglia replacement and explored ways to make it safer and more effective. "This approach is very promising," says Pasqualina Colella, who studies gene and cell therapy at Stanford University School of Medicine in California. "But the caveat is the toxicity of the procedure."
Science
Health
fromwww.nature.com
1 month ago

Therapeutic genetic restoration through allogeneic brain microglia replacement

A brain-restricted microglia replacement approach avoids myeloablation and enhances therapy for lysosomal storage diseases.
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