Science
fromNature
1 week agoAn expanded registry of candidate cis-regulatory elements - Nature
The cCRE registry expanded to 2.37 million human and 967,000 mouse elements and integrates functional characterization for over 97% of human cCREs.
Now, researchers have mapped the key structural changes in the pelvis that enabled early humans to first walk on two legs and accommodate giving birth to a big-brained baby. The study, published in Nature on 27 August, compared the embryonic development of the pelvis between humans and other mammals. They found two key evolutionary steps during embryonic development - related to the growth of cartilage and bone in the pelvis - which put humans on a separate evolutionary path from other apes.
Large-scale genome-wide association studies have identified many complex trait loci related to autoimmune, metabolic, and infectious diseases, yet assigning function to non-coding variants remains challenging.