Cancer
fromwww.bbc.com
4 days agoUniversity explores endometriosis and cancer link
Endometriosis may release chemical signals that help certain ovarian cancers grow, spread, and evade immune responses, enabling improved future treatments.
In a summary of the study, which was partially federally funded, the authors explain that usual drug discovery approaches tackle one protein at a time, and work in cases such as kinase inhibitors -- drugs that prevent cancer cells from expanding by blocking certain proteins -- but can fall short when the disease involves interactions between multiple signaling pathways and genes.
Investigators led by Navdeep Chandel, PhD, have demonstrated that mitochondrial metabolism is crucial for T-cell proliferation and the prevention of T-cell exhaustion in cancer and chronic infection.
The collaboration between researchers at The Institute of Cancer Research and Linköping University has led to significant advancements in understanding telomere biology and its implications for cancer.