Replenishing thymus-derived factors (DLL1, FLT3-L, IL-7) via liver-expressed mRNA restores immune function in aged mice, improving vaccine and cancer immunotherapy responses.
How mRNA Cancer Vaccines Could Treat Pancreatic and Other Types of Cancer
mRNA vaccines are being developed as therapeutic cancer treatments, showing promise where traditional therapies often fail, especially for hard-to-treat cancers like pancreatic cancer.
mRNA vaccines can stimulate immune responses that help the body recognize and attack cancer, enabling potential off-the-shelf cancer vaccines and improving patient survival.
The medicine Nobel Prize goes to 3 scientists for work on peripheral immune tolerance
Discoveries by Brunkow, Ramsdell and Sakaguchi revealed mechanisms of peripheral immune tolerance, enabling therapies for cancer, autoimmune disease, and improved transplants.
Mitochondria Support T-cells Proliferation and Memory Formation - News Center
Investigators led by Navdeep Chandel, PhD, have demonstrated that mitochondrial metabolism is crucial for T-cell proliferation and the prevention of T-cell exhaustion in cancer and chronic infection.
Microbiota-driven antitumour immunity mediated by dendritic cell migration - Nature
Immune checkpoint blockade therapies significantly improve cancer survival but have low complete response rates, necessitating new biomarkers and strategies.