Incyte tops this list due to its rare combination of commercial scale, cash generation, and pipeline depth. The company posted FY2025 revenue of $5.14 billion, up 21.2% YoY, anchored by Jakafi generating $828.2 million in Q4 2025 alone (+7% YoY) and Opzelura delivering $207.3 million (+28% YoY). With $3.58 billion in cash and 14 pivotal clinical trials underway, Incyte offers an acquirer immediate revenue, margin expansion potential, and a deep oncology pipeline spanning KRASG12D, CDK2 inhibition, and mutCALR.
Modern scientific societies are increasingly vulnerable due to their dependence on membership fees and journal subscriptions, which are being challenged by the rise of virtual networking and open-access publishing.
His message is clear: our world is built on abundant energy, around 80% of which has come from fossil fuels over the past 50 years. Because supplies are limited, energy consumption will peak in decades - sooner if humans attempt to limit climate change. To keep global warming below 1.5 °C by 2100, the use of fossil fuels must fall by 5-8% each year - a pace that is too fast for low-carbon energy to keep up with.
Martschenko's argument is largely that genetic research and data have almost always been used thus far as a justification to further entrench extant social inequalities. But we know the solutions to many of the injustices in our world-trying to lift people out of poverty, for example-and we certainly don't need more genetic research to implement them. Trejo's point is largely that more information is generally better than less.
Biology is undergoing a transformation. After centuries of studying life as it evolves naturally, researchers are now using a combination of computation and genome engineering to intervene, generating new proteins and even whole bacteria from scratch. The use of artificial-intelligence tools to design biological components, an approach known as generative biology, is set to turbocharge this area of research. Just last year, scientists used AI-assisted design to produce artificial genes that can be expressed in mammalian cells.
Last November, the UK government announced a bold plan to phase out animal testing in some areas of research. Animal tests for skin irritation are scheduled for elimination this year, and some studies on dogs should be slashed by 2030. The long-term vision is 'a world where the use of animals in science is eliminated in all but exceptional circumstances'.
Over two-thirds said they recommend their students consider careers outside academia. The majority had delayed hiring in their labs, and one-third had laid off workers. More than one in six said they have lost researchers to institutions in other countries since Trump took office. Sixty-eight percent said funding cuts and federal policy changes had moderately or significantly reduced the scope of their work.