"CASP5C, one of the isoforms of CASP5, uniquely promotes Wnt signaling, which is essential for epithelial development and regeneration, by interacting with dishevelled in colonic epithelial cells."
"The interaction of dishevelled with the CASP5 catalytic domain facilitates the bridging of Wnt receptors to the -catenin destruction complex, enhancing Wnt signaling."
"CASP5C cleaves the central scaffold protein APC at Asp556, destabilizing the -catenin destruction complex and thereby promoting Wnt signaling in intestinal stem cells."
"Endogenous and ectopic expression of CASP5C drives the growth of colonic and small intestinal organoids, which is known to require the proliferation of transit-amplifying cells."
CASP5 is an inflammatory caspase involved in inflammation and cell death, with three isoforms identified in the human intestinal epithelium. CASP5C uniquely promotes Wnt signaling, crucial for epithelial development and regeneration. It interacts with dishevelled, linking Wnt receptors to the -catenin destruction complex. CASP5C cleaves the APC protein, destabilizing the -catenin destruction complex and enhancing Wnt signaling. CASP5C expression is highest in transit-amplifying cells, while CASP5A and CASP5B are more prevalent in mature enterocytes. CASP5C drives growth in colonic and small intestinal organoids, requiring transit-amplifying cell proliferation.
Read at www.nature.com
Unable to calculate read time
Collection
[
|
...
]