In the group's study, a "Trojan horse" is used to smuggle a molecule into the brain, where it's then able to change the brain's plasticity, ultimately leading to weight loss. The molecule works by blocking a receptor protein called the NMDA receptor.
"The effect of GLP-1 combined with these molecules is very strong," explained Clemmensen. "In some cases, the mice lose twice as much weight as mice treated with GLP-1 only."
Researchers think that by using the new drug in the future, patients will potentially be able to achieve the same effect from GLP-1 medication with a lower dose, catering to those who haven't responded well to existing drugs like Ozempic and Monjaro.
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