The Antidote to Melancholy: Robert Burton's Centuries-Old Salve for Depression, Epochs Ahead of Science
Briefly

Epochs before modern neuroscience came to locate the crucible of consciousness in the body, centuries before William James proffered his pioneering theory of how our bodies affect our emotions, Robert Burton (February 8, 1577-January 25, 1640) took up these questions in his 1621 tome The Anatomy of Melancholy (public library | public domain), observing that "there is almost no part of the body, which being distempered, doth not cause this malady."
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